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Indications of Esonix 20 mg

Esonix 20 mg is indicated: To alleviate GERD-related symptoms such as persistent heartburn and others. In order to treat erosive esophagitis. To maintain the erosive esophagitis's ability to recover. for the eradication of Helicobacter pylori infection in individuals with duodenal ulcer disease when used in conjunction with amoxicillin and clarithromycin. Syndrome of Zollinger-Ellison. Duodenal & gastric ulcers caused by acid dyspepsia

Dosage of Esonix 20 mg

Healing of Erosive Esophagitis: 20 mg or 40 mg Once Daily for 4-8 Weeks. The majority of patients are healed within 4 to 8 weeks. For patients who don't heal after 4-8 weeks, an additional 4-8 weeks of treatment may be considered. Maintenance of Healing of ErosiveEsophagitis: 20 mg Once Daily (Clinical studies did not extend 6 months). Symptomatic GERD: 20 mg Once Daily for 4 Weeks. If symptoms do not resolve completely after 4 weeks, an additional 4 weeks of treatment may be considered. Helicobacter Pylori eradication: Triple Therapy to reduce the risk of Duodenal Ulcer recurrence-Esomeprazole 40 mg Once Daily for 10 days, Amoxicillin 1000 mg Twice Daily for 10 days, Clarithromycin 500 mg Twice Daily for 10 days.Zollinger-Ellison Syndrome: The dose is 20-80 mg once daily. The dosage should be adjusted individually and treatment continued as long as clinically indicated. Acid-related Dyspepsia: 20-40 mg once daily for 2-4 weeks according to the response. Duodenal ulcer: 20 mg once daily for 2-4 weeks. Gastric ulcer: 20-40 mg once daily for 4-8 weeks.Injection: The recommended adult dose is 40 mg Esonix 20 mg given once daily by intravenous injection (not less than 3 minutes) or intravenous infusion (10 to 30 minutes). Esomeprazole IV injection should not be administered concomitantly with any other medications through the same intravenous site. Treatment with Esomeprazole IV injection should be discontinued as soon as the patient is able to resume treatment with Esomeprazole delayed-release capsules. Safety and effectiveness in paediatric patients have not been established.

Administration of Esonix 20 mg

One hour before a meal, take one Esonix 20 mg pill or capsule and consumed it whole. Delayed-Release Oral Suspension use guidelines: The entire packet's contents should be placed in a little glass with 15 ml of water. After thoroughly stirring the mixer, give it two to three minutes to thicken. Within 30 minutes, stir once more and consume. Add extra water, swirl, and drink right away if any medicine is still present after consumption. If the suspension is to be taken via a nasogastric or gastric tube, 15 ml of water should be placed in the syringe. After shaking the syringe, wait two to three minutes for the suspension to thicken. Within 30 minutes, shake the syringe and administer a gastric or nasogastric injection into the stomach. Use a syringe that is the right size. Shake and ingest any leftover substances from the gastric or nasogastric tube. A gradual intravenous injection of esomeprazole IV is the recommended method of administration. 5 ml of the specified solvent (WFI) is added to the vial to create the IV injection solution. Upon reconstitution, the injection should be administered gradually over a minimum of three minutes. When kept at room temperature up to 30°C, the solution must be used within 12 hours of reconstitution. Nothing needs to be refrigerated. If there are any visible particles in the reconstituted solution, do not use them.

Interaction of Esonix 20 mg

CYP2C19 and CYP3A4 substantially metabolize esomeprazole in the liver. Studies conducted both in vivo and in vitro have demonstrated that esomeprazole is unlikely to inhibit the CYPs 1A2, 2A6, 2C9, 2D6, 2E1, and 3A4. There shouldn't be any clinically significant interactions with medications that these CYP enzymes process. According to studies on drug interactions, esomeprazole does not interact clinically with phenytoin, warfarin, quinidine, clarithromycin, or amoxicillin. The main enzyme that metabolizes esomeprazole, CYP2C19, may be affected by esomeprazole. Diazepam's clearance was reduced by 45% when Esomeprazole 30 mg and diazepam, a CYP2C19 substrate, were taken together. Diazepam plasma levels have been seen to rise 12 hours after dosage and beyond. Esomeprazole reduces the production of stomach acid. As a result, esomeprazole may hinder the absorption of medications whose bioavailability is significantly influenced by gastrointestinal pH. (e.g., ketoconazole, iron salts and digoxin). The pharmacokinetic profile of esomeprazole does not appear to be altered by the co-administration of oral contraceptives, diazepam, phenytoin, or quinidine. Esomeprazole and 14-hydroxy clarithromycin plasma levels have increased as a result of co-administration with clarithromycin, amoxicillin, and other medications.

Contraindications

Those with known hypersensitivity to any of the formulations should not take esomeprazole.

Side Effects of Esonix 20 mg

The side effects of Esonix 20 mg that are most frequently mentioned are headache, diarrhea, nausea, flatulence, abdominal pain, constipation, and dry mouth. When compared to short-term treatment, relevant side events occurring after maintenance therapy up to 12 months do not differ in type.

Precautions & Warnings

General: A positive symptom response to Esonix 20 mg does not rule out the possibility of stomach cancer. Patients should take esomeprazole capsules at least an hour before meals, according to the information. One spoonful of applesauce can be put into an empty bowl, the Esonix 20 mg capsules can be opened, and the pellets inside the capsule can be carefully dumped onto the applesauce for patients who have trouble swallowing capsules. After combining the pellets and applesauce, immediately ingest the mixture. Use only cold applesauce that is soft enough to be taken without chewing. You shouldn't chew or shatter the pellets. It is not advised to keep the pellet/applesauce mixture for later usage. While taking esomeprazole, antacids are acceptable.

Overdose Effects of Esonix 20 mg

Esonix 20 mg has been shown to be deadly in rats at a single oral dose of 510 mg/kg, or nearly 103 times the human dose on the basis of body surface area. The main symptoms of acute poisoning are decreased motor activity, changes in breathing frequency, tremors, ataxia, and sporadic clonic convulsions. Esomeprazole overdoses are not known to have occurred. Esomeprazole has no known particular countermeasure. Dialysis isn't expected to remove esomeprazole because of how widely it is protein bound. If an overdose occurs, symptomatic and supportive care should be provided. The possibility of ingesting numerous drugs needs to be taken into account, just like with any overdose.

Storage Conditions

Keep in a dry area at a temperature that does not go above 30°C. shield from moisture and light. Keep out of children's reach.

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